abstract：BACKGROUND:The collective cognitive and motor deficits known as HIV-associated neurocognitive disorders (HAND) remain high even among HIV+ individuals whose antiretroviral therapy is optimized. HAND is worsened in the context of opiate abuse. The mechanism of exacerbation remains unclear but likely involves chronic imm...

journal_title：Journal of neuroinflammation

authors： Kim S,Hahn YK,Podhaizer EM,McLane VD,Zou S,Hauser KF,Knapp PE

更新日期：2018-10-10 00:00:00

abstract：BACKGROUND:Fractalkine (CX3CL1) and its receptor (CX3CR1) play an important role in regulating microglial function. We have previously shown that Cx3cr1 deficiency exacerbated tau pathology and led to cognitive impairment. However, it is still unclear if the chemokine domain of the ligand CX3CL1 is essential in regulat...

journal_title：Journal of neuroinflammation

authors： Bemiller SM,Maphis NM,Formica SV,Wilson GN,Miller CM,Xu G,Kokiko-Cochran ON,Kim KW,Jung S,Cannon JL,Crish SD,Cardona AE,Lamb BT,Bhaskar K

更新日期：2018-09-25 00:00:00

abstract：BACKGROUND:Repetitive mild traumatic brain injuries (rmTBI) are associated with cognitive deficits, inflammation, and stress-related events. We tested the effect of nutrient intake on the impact of rmTBI in an animal model of chronic traumatic encephalopathy (CTE) to study the pathophysiological mechanisms underlying t...

journal_title：Journal of neuroinflammation

authors： Yu J,Zhu H,Taheri S,Mondy W,Perry S,Kindy MS

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:The FDA-approved small-molecule drug ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib inhibits Bruton's tyrosine kinase (BTK), a kinase involved in B cell receptor signaling. However, the potential regulation of neuroinflammatory responses in the brai...

journal_title：Journal of neuroinflammation

authors： Nam HY,Nam JH,Yoon G,Lee JY,Nam Y,Kang HJ,Cho HJ,Kim J,Hoe HS

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:Mice with pilocarpine-induced temporal lobe epilepsy (TLE) are characterized by intense hippocampal neuroinflammation, a prominent pathological hallmark of TLE that is known to contribute to neuronal hyperexcitability. Recent studies indicate that Adam10, a member of a disintegrin and metalloproteinase domai...

journal_title：Journal of neuroinflammation

authors： Zhu X,Li X,Zhu M,Xu K,Yang L,Han B,Huang R,Zhang A,Yao H

更新日期：2018-08-04 00:00:00

abstract：BACKGROUND:The glutamine synthetase (GS), an astrocyte-specific enzyme, is involved in lipopolysaccharide (LPS)-induced inflammation which activates the mitogen-activated protein kinase (MAPK) signaling. Endocannabinoid 2-arachidonyl glycerol (2-AG) has been described to serve as an endogenous mediator of analgesia and...

journal_title：Journal of neuroinflammation

authors： Wang S,Zhang H,Geng B,Xie Q,Li W,Deng Y,Shi W,Pan Y,Kang X,Wang J

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:There is a need for clinically useful biomarkers of disease activity in clinically isolated syndrome (CIS) and relapsing remitting MS (RRMS). The aim of this study was to assess the correlation between neurofilament light chain (NFL) in cerebrospinal fluid (CSF) and serum and the relationship between NFL and...

journal_title：Journal of neuroinflammation

authors： Håkansson I,Tisell A,Cassel P,Blennow K,Zetterberg H,Lundberg P,Dahle C,Vrethem M,Ernerudh J

更新日期：2018-07-18 00:00:00

abstract：BACKGROUND:Diabetic neuropathy (DN) is a frequent and debilitating manifestation of diabetes mellitus, to which there are no effective therapeutic approaches. Mesenchymal stem/stromal cells (MSC) have a great potential for the treatment of this syndrome, possibly through regenerative actions on peripheral nerves. Here,...

journal_title：Journal of neuroinflammation

authors： Evangelista AF,Vannier-Santos MA,de Assis Silva GS,Silva DN,Juiz PJL,Nonaka CKV,Dos Santos RR,Soares MBP,Villarreal CF

更新日期：2018-06-22 00:00:00

abstract：BACKGROUND:Necrotizing enterocolitis (NEC) is an acute gut inflammatory disorder that occurs in preterm infants in the first weeks after birth. Infants surviving NEC often show impaired neurodevelopment. The mechanisms linking NEC lesions with later neurodevelopment are poorly understood but may include proinflammatory...

journal_title：Journal of neuroinflammation

authors： Sun J,Pan X,Christiansen LI,Yuan XL,Skovgaard K,Chatterton DEW,Kaalund SS,Gao F,Sangild PT,Pankratova S

更新日期：2018-06-09 00:00:00

abstract：BACKGROUND:Bacterial meningitis is associated with high mortality and long-term neurological sequelae. Increasing the phagocytic activity of microglia could improve the resistance of the CNS against infections. We studied the influence of activin A, a member of the TGF-β family with known immunoregulatory and neuroprot...

journal_title：Journal of neuroinflammation

authors： Diesselberg C,Ribes S,Seele J,Kaufmann A,Redlich S,Bunkowski S,Hanisch UK,Michel U,Nau R,Schütze S

更新日期：2018-06-07 00:00:00

abstract：BACKGROUND:Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) specifically using hSOD1 transgenic animals; however, a comprehensive examination of complement expression in other transgenic ALS models has not been performed. This study theref...

journal_title：Journal of neuroinflammation

authors： Lee JD,Levin SC,Willis EF,Li R,Woodruff TM,Noakes PG

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Atypical chemokine receptor 3 (ACKR3, synonym CXCR7) is increasingly considered relevant in neuroinflammatory conditions, in which its upregulation contributes to compromised endothelial barrier function and may ultimately allow inflammatory brain injury. While an impact of ACKR3 has been recognized in sever...

journal_title：Journal of neuroinflammation

authors： Silwedel C,Speer CP,Haarmann A,Fehrholz M,Claus H,Buttmann M,Glaser K

更新日期：2018-05-23 00:00:00

abstract：BACKGROUND:Immune activation, specifically activation of macrophages and resident microglia, leading to inflammation is a key component in the progression of spinal cord injury (SCI). Macrophages/microglia exist in two states-the classically activated M1 phenotype that confers pro-inflammatory effects or the alternativ...

journal_title：Journal of neuroinflammation

authors： Xu S,Zhu W,Shao M,Zhang F,Guo J,Xu H,Jiang J,Ma X,Xia X,Zhi X,Zhou P,Lu F

更新日期：2018-05-22 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is characterized by selective degeneration of dopaminergic (DA) neurons of the substantia nigra pars compacta (SN) while neighboring ventral tegmental area (VTA) DA neurons are relatively spared. Mechanisms underlying the selective protection of the VTA and susceptibility of the SN a...

journal_title：Journal of neuroinflammation

authors： Kostuk EW,Cai J,Iacovitti L

更新日期：2018-05-11 00:00:00

abstract：BACKGROUND:Interleukin-33 (IL-33) is increasingly being recognized as a key immunomodulatory cytokine in many neurological diseases. METHODS:In the present study, wild-type (WT) and IL-33-/- mice received intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) to induce neuroinflammation. Intravital mic...

journal_title：Journal of neuroinflammation

authors： Cao K,Liao X,Lu J,Yao S,Wu F,Zhu X,Shi D,Wen S,Liu L,Zhou H

更新日期：2018-05-04 00:00:00

abstract：BACKGROUND:Ischemic stroke induced matrixmetallo-proteinase-9 (MMP-9) upregulation, which increased blood-brain barrier permeability. Studies demonstrated that mesenchymal stem cell therapy protected blood-brain barrier disruption from several cerebrovascular diseases. However, the underlying mechanism was largely unkn...

journal_title：Journal of neuroinflammation

authors： Cheng Z,Wang L,Qu M,Liang H,Li W,Li Y,Deng L,Zhang Z,Yang GY

更新日期：2018-05-03 00:00:00

abstract：BACKGROUND:Multiple risk factors contribute to the progression of Parkinson's disease, including oxidative stress and neuroinflammation. Epidemiological studies have revealed a link between higher urate level and a lower risk of developing PD. However, the mechanistic basis for this association remains unclear. Urate p...

journal_title：Journal of neuroinflammation

authors： Bao LH,Zhang YN,Zhang JN,Gu L,Yang HM,Huang YY,Xia N,Zhang H

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Brain inflammation including increases in inflammatory cytokines such as IL-1β is widely believed to contribute to the pathophysiology of Alzheimer's disease. Although IL-1β-induced impairments in long-term potentiation (LTP) in acute hippocampal slices and memory functions in vivo have been well documented,...

journal_title：Journal of neuroinflammation

authors： Tong L,Prieto GA,Cotman CW

更新日期：2018-04-30 00:00:00

abstract：BACKGROUND:Both dysfunctional neuropeptide signaling and immune system activation are characteristic of complex regional pain syndrome (CRPS). Unknown is whether substance P (SP) or calcitonin gene-related peptide (CGRP) support autoantibody production and, consequently, nociceptive sensitization. METHODS:These experi...

journal_title：Journal of neuroinflammation

authors： Li WW,Guo TZ,Shi X,Birklein F,Schlereth T,Kingery WS,Clark JD

更新日期：2018-04-11 00:00:00

abstract：BACKGROUND:A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing basis for the development of analgesics. In a murine VCR model, CX3...

journal_title：Journal of neuroinflammation

authors： Montague K,Simeoli R,Valente J,Malcangio M

更新日期：2018-04-06 00:00:00

abstract：BACKGROUND:Glia-mediated neuroinflammation is related to brain injury exacerbation after cerebral ischemia/reperfusion (I/R) injury. Astrocytic hemichannels or gap junctions, which were mainly formed by connexin-43, have been implicated in I/R damage. However, the exact roles of astrocytic hemichannels and gap junction...

journal_title：Journal of neuroinflammation

authors： Yin X,Feng L,Ma D,Yin P,Wang X,Hou S,Hao Y,Zhang J,Xin M,Feng J

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Mer tyrosine kinase (MerTK) activity necessary for amyloid-stimulated phagocytosis strongly implicates that MerTK dysregulation might contribute to chronic inflammation implicated in Alzheimer's disease (AD) pathology. However, the precise mechanism involved in the regulation of MerTK expression by amyloid-β...

journal_title：Journal of neuroinflammation

authors： Jhang KA,Park JS,Kim HS,Chong YH

更新日期：2018-03-12 00:00:00

abstract：BACKGROUND:The cystine/glutamate antiporter (xc-) has been implicated in several neurological disorders and, specifically, in multiple sclerosis (MS) as a mediator of glutamate excitotoxicity and proinflammatory immune responses. We aimed to evaluate an xc-specific positron emission tomography (PET) radiotracer, (4S)-4...

journal_title：Journal of neuroinflammation

authors： Hoehne A,James ML,Alam IS,Ronald JA,Schneider B,D'Souza A,Witney TH,Andrews LE,Cropper HC,Behera D,Gowrishankar G,Ding Z,Wyss-Coray T,Chin FT,Biswal S,Gambhir SS

更新日期：2018-02-22 00:00:00

abstract：BACKGROUND:We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials. We also demonstrated that dynorphin possesses anti-inflammatory and antioxidant potentials against dopaminergic loss, and that balance between dynor...

journal_title：Journal of neuroinflammation

authors： Dang DK,Shin EJ,Kim DJ,Tran HQ,Jeong JH,Jang CG,Nah SY,Jeong JH,Byun JK,Ko SK,Bing G,Hong JS,Kim HC

更新日期：2018-02-21 00:00:00

abstract：:Traumatic brain injury (TBI) is an important cause of disability and mortality in the western world. While the initial injury sustained results in damage, it is the subsequent secondary cascade that is thought to be the significant determinant of subsequent outcomes. The changes associated with the secondary injury do...

journal_title：Journal of neuroinflammation

authors： Hammad A,Westacott L,Zaben M

更新日期：2018-01-22 00:00:00

abstract：BACKGROUND:Age-related macular degeneration (AMD) is a devastating eye disease causing irreversible vision loss in the elderly. Retinal pigment epithelium (RPE), the primary cell type that is afflicted in AMD, undergoes programmed cell death in the late stages of the disease. However, the exact mechanisms for RPE degen...

journal_title：Journal of neuroinflammation

authors： Gao J,Cui JZ,To E,Cao S,Matsubara JA

更新日期：2018-01-12 00:00:00

abstract：BACKGROUND:This study aims to explore the role of indoleamine-2,3-dioxygenase (IDO)/kynurenine (KYN) pathway of tryptophan (TRY) metabolism in behavioral alterations observed in hepatic encephalopathy (HE) rats. METHODS:Expression levels of proinflammatory cytokines were tested by QT-PCR and ELISA, levels of IDOs were...

journal_title：Journal of neuroinflammation

authors： Jiang X,Xu L,Tang L,Liu F,Chen Z,Zhang J,Chen L,Pang C,Yu X

更新日期：2018-01-04 00:00:00

abstract：BACKGROUND:Neuroinflammation and a systemic inflammatory reaction are important features of perinatal asphyxia. Neuroinflammation may have dual aspects being a hindrance, but also a significant help in the recovery of the CNS. We aimed to assess intracellular cytokine levels of T-lymphocytes and plasma cytokine levels ...

journal_title：Journal of neuroinflammation

authors： Bajnok A,Berta L,Orbán C,Veres G,Zádori D,Barta H,Méder Ü,Vécsei L,Tulassay T,Szabó M,Toldi G

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:The aim of the research is to study the human leukocyte antigen (HLA) class II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies. METHODS:Thirteen anti-NF155+ and 35 anti-NF155 negative (anti-NF155neg) CIDP patients...

journal_title：Journal of neuroinflammation

authors： Martinez-Martinez L,Lleixà MC,Boera-Carnicero G,Cortese A,Devaux J,Siles A,Rajabally Y,Martinez-Piñeiro A,Carvajal A,Pardo J,Delmont E,Attarian S,Diaz-Manera J,Callegari I,Marchioni E,Franciotta D,Benedetti L,Lauria G,

更新日期：2017-11-16 00:00:00

abstract：BACKGROUND:Extracellular matrix (ECM) proteins play critical functions regulating vascular formation and function. Laminin is a major component of the vascular basal lamina, and transgenic mice deficient in astrocyte or pericyte laminin show defective blood-brain barrier (BBB) integrity, indicating an important instruc...

journal_title：Journal of neuroinflammation

authors： Welser JV,Halder SK,Kant R,Boroujerdi A,Milner R

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain areas in Alzheimer's disease. METHODS:Here, we investigated whether the overexpression of DHCR24 prot...

journal_title：Journal of neuroinflammation

authors： Martiskainen H,Paldanius KMA,Natunen T,Takalo M,Marttinen M,Leskelä S,Huber N,Mäkinen P,Bertling E,Dhungana H,Huuskonen M,Honkakoski P,Hotulainen P,Rilla K,Koistinaho J,Soininen H,Malm T,Haapasalo A,Hiltunen M

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:Abundant reports indicated that depression was often comorbid with type 2 diabetes and even metabolic syndrome. Considering they might share common biological origins, it was tentatively attributed to the chronic cytokine-mediated inflammatory response which was induced by dysregulation of HPA axis and overa...

journal_title：Journal of neuroinflammation

authors： Su WJ,Peng W,Gong H,Liu YZ,Zhang Y,Lian YJ,Cao ZY,Wu R,Liu LL,Wang B,Wang YX,Jiang CL

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system that preferentially affects the optic nerves, spinal cord, and area postrema. A series of evidence suggested that B cells play a fundamental role in the pathogenesis of NMOSD. However, there are...

journal_title：Journal of neuroinflammation

authors： Kong BS,Kim Y,Kim GY,Hyun JW,Kim SH,Jeong A,Kim HJ

更新日期：2017-09-25 00:00:00

abstract：BACKGROUND:Recent evidence has suggested that peripheral inflammatory responses induced by lipopolysaccharides (LPS) play an important role in neuropsychiatric dysfunction in rodents. Interleukin-1β (IL-1β), a pro-inflammatory cytokine, has been proposed to be a key mediator in a variety of behavioral dysfunction induc...

journal_title：Journal of neuroinflammation

authors： Li M,Li C,Yu H,Cai X,Shen X,Sun X,Wang J,Zhang Y,Wang C

更新日期：2017-09-20 00:00:00

abstract：BACKGROUND:There has been a marked increase in the incidence of autoimmune diseases like multiple sclerosis (MS) in the last decades which is most likely driven by a change in environmental factors. Here, growing evidence suggests that ingredients of a Western diet like high intake of sodium chloride (NaCl) or saturate...

journal_title：Journal of neuroinflammation

authors： Hammer A,Schliep A,Jörg S,Haghikia A,Gold R,Kleinewietfeld M,Müller DN,Linker RA

更新日期：2017-09-12 00:00:00

abstract：BACKGROUND:Recent evidence suggests that exposure to intrauterine inflammation causes acute fetal brain injury and is linked to a spectrum of neurobehavioral disorders. In a rodent model of intrauterine inflammation induced by lipopolysaccharide (LPS) exposure in utero, activated microglia can be detected in the hippoc...

journal_title：Journal of neuroinflammation

authors： Kelley MH,Wu WW,Lei J,McLane M,Xie H,Hart KD,Pereira L,Burd I,Maylie J

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Activated astrocytes release matrix metalloproteinase-2/9 (MMP-2/9) to induce central sensitization and maintain neuropathic pain. However, the mechanisms involved in the activation of MMP-2/9 on astrocytes during pain remain poorly understood. Meanwhile, there is a lack of effective treatment to inhibit the...

journal_title：Journal of neuroinflammation

authors： Jiang L,Pan CL,Wang CY,Liu BQ,Han Y,Hu L,Liu L,Yang Y,Qu JW,Liu WT

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:Streptococcus pneumoniae meningitis is a serious inflammatory disease of the central nervous system (CNS) and is associated with high morbidity and mortality rates. The inflammatory processes initiated by recognition of bacterial components contribute to apoptosis in the hippocampal dentate gyrus. Brain-deri...

journal_title：Journal of neuroinflammation

authors： Xu D,Lian D,Wu J,Liu Y,Zhu M,Sun J,He D,Li L

更新日期：2017-08-04 00:00:00

abstract：BACKGROUND:Microglial activation and the subsequent inflammatory response in the central nervous system play important roles in secondary damage after traumatic brain injury (TBI). High-mobility group box 1 (HMGB1) protein, an important mediator in late inflammatory responses, interacts with transmembrane receptor for ...

journal_title：Journal of neuroinflammation

authors： Chen X,Wu S,Chen C,Xie B,Fang Z,Hu W,Chen J,Fu H,He H

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammation, oligodendrocyte loss, demyelination, and axonal degeneration. Cyclic phosphatidic acid (cPA) is...

journal_title：Journal of neuroinflammation

authors： Yamamoto S,Yamashina K,Ishikawa M,Gotoh M,Yagishita S,Iwasa K,Maruyama K,Murakami-Murofushi K,Yoshikawa K

更新日期：2017-07-21 00:00:00